ENTRAF

The DNA-binding transcription factors (TFs) have a fundamental role to contend with environmental changes in all the organisms. These proteins affect gene expression positively and/or negatively depending on operator context and ligand-binding status. Prediction and characterization of a novel TFs generally involve finding a function for a protein considering a reference dataset (golden standard), which include the information of well-annotated proteins with experimental evidence. Most TFs have been identified and collected from diverse databases, such as uniprot, regulonDB or DBTBS. This database provides a centralized, web-based location to organize information about TFs for which there is strong experimental evidence.